Serengeti National Park is a large national park in Northern Tanzania located eastern Mara region covering an area of 14,740 square Kilometers. Serengeti National Park forms a Lion Conservation Unit since 2005 together with Maasai Mara National Reserve. More than 3,000 lions live in this ecosystem. The population density of the African leopard is estimated at 5.41 individuals per 100 km2 (39 sq. mi) in the dry season. All the big five can be spotted at Serengeti plains.

Other mammal carnivores include the cheetah, about 3,500 spotted hyena, two species of jackals, African golden wolf, honey badger, striped hyena, caracal, serval, seven species of mongooses, and two species of otters. The East African wild dog was reintroduced to the area in 2012 after disappearing in 1991. Other mammals include aardvark, aardwolf, african wildcat, african civet, common genet, zorilla, african striped weasel, bat-eared fox, ground pangolin, crested porcupine, three species of hyraxes and cape hare. Primates such as yellow and olive baboons, patas monkeys, and vervet monkey, black-and-white colobus are also seen in the gallery forests of the Grumeti River. More than 500 bird species can be seen in the park.